A Preliminary Assessment of Perceived and Objectively Scaled Workload of a Voice-Based Driver Interface

Interaction with a voice-command interface for radio control, destination entry, MP3 song selection, and phone dialing was assessed along with traditional manual radio control and a multi-level audio–verbal calibration task (nback) on-road in 60 drivers. Subjective workload, compensatory behavior, and physiological indices of cognitive workload suggest that there may be both potential benefits and cautions in the implementation of a representative production level interface

The LDBC Graphalytics Benchmark

In this document, we describe LDBC Graphalytics, an industrial-grade benchmark for graph analysis platforms. The main goal of Graphalytics is to enable the fair and objective comparison of graph analysis platforms. Due to the diversity of bottlenecks and performance issues such platforms need to address, Graphalytics consists of a set of selected deterministic algorithms for full-graph analysis, standard graph datasets, synthetic dataset generators, and reference output for validation purposes. Its test harness produces deep metrics that quantify multiple kinds of systems scalability, weak and strong, and robustness, such as failures and performance variability. The benchmark also balances comprehensiveness with runtime necessary to obtain the deep metrics. The benchmark comes with open-source software for generating performance data, for validating algorithm results, for monitoring and sharing performance data, and for obtaining the final benchmark result as a standard performance report

LDBC Graphalytics: A Benchmark for Large-Scale Graph Analysis on Parallel and Distributed Platforms

ABSTRACT In this paper we introduce LDBC Graphalytics, a new industrial-grade benchmark for graph analysis platforms. It consists of six deterministic algorithms, standard datasets, synthetic dataset generators, and reference output, that enable the objective comparison of graph analysis platforms. Its test harness produces deep metrics that quantify multiple kinds of system scalability, such as horizontal/vertical and weak/strong, and of robustness, such as failures and performance variability. The benchmark comes with open-source software for generating data and monitoring performance. We describe and analyze six implementations of the benchmark (three from the community, three from the industry), providing insights into the strengths and weaknesses of the platforms. Key to our contribution, vendors perform the tuning and benchmarking of their platforms

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification in vitro. Conversely, vascular calcification can be reduced by calcimimetics, which function as allosteric activators of CaSR. Methods To determine the role of the CaSR in vascular calcification, we characterized mice with targeted Casr gene knockout in vascular smooth muscle cells (SM22αCaSRΔflox/Δflox). Results Vascular smooth muscle cells cultured from the knockout (KO) mice calcified more readily than those from control (wild-type) mice in vitro. However, mice did not show ectopic calcifications in vivo but they did display a profound mineral ion imbalance. Specifically, KO mice exhibited hypercalcemia, hypercalciuria, hyperphosphaturia, and osteopenia, with elevated circulating fibroblast growth factor 23 (FGF23), calcitriol (1,25-D3), and parathyroid hormone levels. Renal tubular α-Klotho protein expression was increased in KO mice but vascular α-Klotho protein expression was not. Altered CaSR expression in the kidney or the parathyroid glands could not account for the observed phenotype of the KO mice. Conclusions These results suggest that, in addition to CaSR’s established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis

LDBC Graphalytics: A Benchmark for Large-Scale Graph Analysis on Parallel and Distributed Platforms

In this paper we introduce LDBC Graphalytics, a new industrial-grade benchmark for graph analysis platforms. It consists of six deterministic algorithms, standard datasets, synthetic dataset generators, and reference output, that enable the objective comparison of graph analysis platforms. Its test harness produces deep metrics that quantify multiple kinds of system scalability, such as horizontal/vertical and weak/strong, and of robustness, such as failures and performance variability. The benchmark comes with open-source software for generating data and monitoring performance. We describe and analyze six implementations of the benchmark (three from the community, three from the industry), providing insights into the strengths and weaknesses of the platforms. Key to our contribution, vendors perform the tuning and benchmarking of their platforms